Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques

Maphis NM, Hulse J, Peabody J, Dadras S, Whelpley MJ, Kandath M, Wilson C, Hobson S, Thompson J, Poolsup S, Beckman D, Ott SP, Watanabe JW, Usachenko JL, Van Rompay KK, Morrison J, Selwyn R, Rosenberg G, Knoefel J, Chackerian B, Bhaskar K.Alzheimers Dement. Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques. 2025 Mar;21(3):e70101. doi: 10.1002/alz.70101. PMID: 40145301